Weenie – who appears to actually be a hot dog in a bun – is a deuteragonist of “Oswald” alongside her owner, the titular blue octopus.
Weenie is a loyal and affectionate pet who keeps Oswald focused, and stops him from getting carried away on an idea. She loves to play frisbee or with a ball of yarn, and also enjoys howling along as Oswald plays the piano. She communicates in “bark-speak,” doing her best to tell Oswald what she knows. She loves ice cream and sticks with her owner through thick and thin since the very first episode. Her last appearance was the final episode of the show.
Snowball II from “The Simpsons”
Why name a black cat after something that is, traditionally, white? Because Snowball II is named after her predecessor...Snowball. Who was white. Snowball II reigned in the Simpsons household from 1985 to 2004, until Doctor Hibbert's Mercedes-Benz hit her. Lisa went through a number of pets, eventually settling on a cat that was identical to Snowball II in every way. Including, after a bit of thought, her name.
The cat has a good relationship with the other household pet, Santa's Little Helper, and often tries hard to get the attention of Lisa and the rest of the family when she feels ignored.
Brian from “Family Guy”
Hardly even a pet, this dog makes it onto the list via being a nominal member of the family. He walks and talks like a human, drinks, drives, is trying to make his way as a writer, and gets into fights.
Most often seen with toddler Stewie, the two travel through time and save the world. Brian also spends a lot of time with his owner, Peter Griffin. This dog even dates human women, which can raise some eyebrows. Still, he sticks with his friends and family and usually tries to help them out, which means he certainly counts as a loyal pet. But just barely.
Rufus from “Kim Possible”
He isn't a cat or a dog, but if anybody tries to separate Rufus from his loving owner Ron Stoppable, there's going to be trouble. This cute little naked mole-rat doesn't even have any fur, but he still loves Tex-Mex, adventures, and Kim, just like Ron does.
It's hard to count the number of times Rufus has gotten Kim or Ron out of sticky situations, or the number of times that Rufus has bombed Ron's schemes to be more popular or cooler in school. He's voiced by Nancy Cartwright, who is best known for her long-running role as Bart Simpson.
Astro Jetson from “The Jetsons”
As the space-age mirror to the stone-age Flintstones, the Jetsons presented their own take on modern life, showing us the far-flung future. Astro is the family dog that first appeared with the family in 1962.
Even though he causes plenty of stress to owner George Jetson, Astro is a best friend to the family. Though clumsy and dim-witted, he's loyal to everyone in the family. The dog can talk in rough “dog-sounding” English thanks to Don Messick. If you've ever thought that Scooby and Astro sound similar, that's because they share Messick and basically have the same voice.